Epidemiologic studies have suggested that dietary factors may reduce risk of lung cancer. In the January 15 issue of Cancer Research, Christine A. Stidley and colleagues evaluated whether diet and multivitamin use influenced the prevalence of gene promoter methylation in cells exfoliated from the aerodigestive tract of current and former smokers in the Lovelace Smokers Cohort. The study observed that consumption of leafy green vegetables and folate provided significant protection against gene methylation; protection was also seen with multivitamin use.